Efficacy and safety of omalizumab treatment to facilitate successful oral desensitisation in high-risk milk-allergic patients
نویسندگان
چکیده
Background One of the most promising therapies in persistent and severe food allergy is oral immunotherapy (OIT), with immediate goal of desensitization and long-term goal of tolerance. However, a subgroup of patients may experience severe allergic reactions. These concerns might be addressed by combination of OIT with another promising therapy involving anti-IgE monoclonal antibodies (omalizumab), which can reduce allergic reactions associated with food administration.
منابع مشابه
A pilot study of omalizumab to facilitate rapid oral desensitization in high-risk peanut-allergic patients.
BACKGROUND Peanut allergy is a major public health problem that affects 1% of the population and has no effective therapy. OBJECTIVE To examine the safety and efficacy of oral desensitization in peanut-allergic children in combination with a brief course of anti-IgE mAb (omalizumab [Xolair]). METHODS We performed oral peanut desensitization in peanut-allergic children at high risk for devel...
متن کاملRecent Progress in Allergen Immunotherapy
The efficacy of allergen immunotherapy for the treatment of allergic rhinoconjunctivitis with or without seasonal bronchial asthma and anaphylaxis caused by the sting of the hymenoptera class of insects has been clearly demonstrated in numerous well-designed, placebo-controlled trials. Immunotherapy whether by subcutaneous injection of allergen extract or by oral/sublingual routes modifies peri...
متن کاملReduction in oral corticosteroid use in patients receiving omalizumab for allergic asthma in the real-world setting
BACKGROUND Oral corticosteroids (OCS) are commonly administered in patients with severe persistent allergic asthma. Despite their efficacy, they are associated with a wide variety of adverse events. The eXpeRience registry was set up to investigate real-world outcomes among patients receiving omalizumab for the treatment of uncontrolled allergic asthma. Here, we present the effect of omalizumab...
متن کاملOmalizumab: Clinical Use for the Management of Asthma
Omalizumab, a humanized monoclonal antibody that binds circulating IgE antibody, is a treatment option for patients with moderate to severe allergic asthma whose asthma is poorly controlled with inhaled corticosteroids and inhaled long-acting β(2) agonist bronchodilators. This review considers the mechanism of action, pharmacokinetics, efficacy, safety and place in management of omalizumab in a...
متن کاملLong-term efficacy and safety of omalizumab in patients with persistent uncontrolled allergic asthma: a systematic review and meta-analysis
Currently, limited information is available to clinicians regarding the long-term efficacy of omalizumab treatment for allergic asthma. In this report, we aimed to (i) systematically review the evidence regarding the long-term efficacy of omalizumab in patients with persistent uncontrolled allergic asthma, and to (ii) discuss the cost-effectiveness evidence published for omalizumab in this pati...
متن کامل